Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Insulin Resistance: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Associated Genes | ALZHEIMER, DIABETES MELLITUS, ALZHEIMER'S DISEASE, INSULIN RESISTANCE, ROS, INFLAMMATION, AKT, AUTOPHAGY |
| Therapeutic Agents | Anti-diabetic Drugs, Spermidine, Metformin, Intranasal Insulin, PD-1 Blockade, Anti-Diabetic Drugs |
| KG Connections | 813 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
Insulin_Resistance["<b>Insulin Resistance</b>"]
Oxidative_Stress["Oxidative Stress"]
Insulin_Resistance -->|"activates"| Oxidative_Stress
Insulin_Signaling["Insulin Signaling"]
Insulin_Resistance -->|"activates"| Insulin_Signaling
Lipid_Metabolism["Lipid Metabolism"]
Insulin_Resistance -->|"activates"| Lipid_Metabolism
Nf__b["Nf-Kappab"]
Insulin_Resistance -->|"activates"| Nf__b
Autophagy["Autophagy"]
Insulin_Resistance -->|"activates"| Autophagy
Mitophagy["Mitophagy"]
Insulin_Resistance -->|"activates"| Mitophagy
INSULIN_RESISTANCE(["INSULIN RESISTANCE"])
INSULIN_RESISTANCE -->|"contributes_to"| Insulin_Resistance
DIABETES_MELLITUS(["DIABETES MELLITUS"])
DIABETES_MELLITUS -->|"associated_with"| Insulin_Resistance
Diabetes{"Diabetes"}
Diabetes -->|"associated_with"| Insulin_Resistance
Type_2_Diabetes{"Type 2 Diabetes"}
Type_2_Diabetes -->|"associated_with"| Insulin_Resistance
style Insulin_Resistance fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Oxidative Stress | activates | pathway | 1.00 |
| Insulin Signaling | activates | pathway | 1.00 |
| Lipid Metabolism | activates | pathway | 1.00 |
| Type 2 Diabetes Mellitus | associated_with | disease | 0.95 |
| Advanced Glycation End Products | causes | compound | 0.90 |
| Metabolic Syndrome | associated_with | disease | 0.90 |
| Alzheimer's Disease | contributes_to | disease | 0.90 |
| Muscle Wasting | causes | phenotype | 0.90 |
| Neurodegeneration | causes | process | 0.90 |
| Alzheimer'S Disease | contributes_to | disease | 0.90 |
| Ages | promotes | compound | 0.90 |
| Mitochondrial Dysfunction | causes | process | 0.90 |
| Inflammation | promotes | process | 0.90 |
| Apoptosis | promotes | process | 0.90 |
| Nf-Κb | activates | pathway | 0.90 |
| Autophagy | activates | pathway | 0.90 |
| Mitophagy | activates | pathway | 0.90 |
| Oxidative Stress | associated_with | pathway | 0.90 |
| Apoptosis | implicated_in | pathway | 0.90 |
| Alzheimer's Disease | risk_factor_for | disease | 0.85 |
| Diabetes | associated_with | disease | 0.85 |
| Neurodegeneration | risk_factor_for | process | 0.85 |
| Neurodegenerative Disease Risk | risk_factor_for | phenotype | 0.85 |
| Alzheimer's Disease | associated_with | disease | 0.85 |
| Parkinson's Disease | associated_with | disease | 0.85 |
| Non-Alcoholic Fatty Liver Disease | contributes_to | disease | 0.85 |
| PARKINSON'S DISEASE | risk_factor_for | disease | 0.85 |
| ALZHEIMER'S DISEASE | risk_factor_for | disease | 0.85 |
| ALS | risk_factor_for | disease | 0.85 |
| Neurodegeneration | contributes_to | process | 0.85 |
| Inflammation | contributes_to | process | 0.80 |
| Insulin Signaling | contributes_to | pathway | 0.80 |
| Oxidative Stress | inhibits | pathway | 0.80 |
| Autophagy | implicated_in | pathway | 0.80 |
| Apoptosis | activates | pathway | 0.80 |
| Microbiota | regulates | pathway | 0.80 |
| Cholesterol | associated_with | pathway | 0.80 |
| Lipid Metabolism | associated_with | pathway | 0.80 |
| Oxidative Stress | contributes_to | pathway | 0.80 |
| Oxidative Stress | treats | pathway | 0.80 |
| Blood-Brain Barrier | associated_with | pathway | 0.80 |
| Inflammation | associated_with | process | 0.75 |
| Mitochondrial Dysfunction | associated_with | process | 0.75 |
| Fatty Liver | activates | disease | 0.75 |
| Parkinson's Disease | risk_factor_for | disease | 0.75 |
| Autophagy | contributes_to | pathway | 0.70 |
| Microbiota | inhibits | pathway | 0.70 |
| Nf-Κb | inhibits | pathway | 0.70 |
| Oxidative Stress | therapeutic_target | pathway | 0.70 |
| Nf-Κb | contributes_to | pathway | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| INSULIN RESISTANCE | contributes_to | gene | 1.00 |
| DIABETES MELLITUS | associated_with | gene | 1.00 |
| Diabetes | associated_with | disease | 1.00 |
| Type 2 Diabetes | associated_with | disease | 1.00 |
| INSULIN RESISTANCE | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| Obesity | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| Diabetes | therapeutic_target | disease | 1.00 |
| INSULIN RESISTANCE | associated_with | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| Metabolic Syndrome | associated_with | disease | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Obesity | associated_with | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Als | implicated_in | disease | 1.00 |
| INSULIN RESISTANCE | inhibits | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| Als | activates | disease | 1.00 |
| EXERCISE | activates | gene | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | activates | gene | 1.00 |
| Diabetes | activates | disease | 1.00 |
| INSULIN RESISTANCE | therapeutic_target | gene | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Hypertension | associated_with | disease | 1.00 |
| Type 2 Diabetes | therapeutic_target | disease | 1.00 |
| AMPK | activates | gene | 1.00 |
| Type 2 Diabetes Mellitus | causes | disease | 0.95 |
| Inflammation | therapeutic_target | disease | 0.95 |
| AKT | activates | gene | 0.95 |
| INSULIN RESISTANCE | causes | gene | 0.95 |
| INFLAMMATION | treats | gene | 0.95 |
| Diabetes | regulates | disease | 0.95 |
| Alzheimer | activates | disease | 0.95 |
| Type 2 Diabetes | activates | disease | 0.95 |
| NF-ΚB | activates | gene | 0.95 |
| ALZHEIMER | therapeutic_target | gene | 0.95 |
| DIABETES MELLITUS | therapeutic_target | gene | 0.95 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 0.95 |
| ALZHEIMER | implicated_in | gene | 0.95 |
| ALZHEIMER'S DISEASE | implicated_in | gene | 0.95 |
| CYTOKINES | activates | gene | 0.95 |
| DIABETES MELLITUS | activates | gene | 0.95 |
| AUTOPHAGY | activates | gene | 0.95 |
| MITOPHAGY | activates | gene | 0.95 |
| IL-6 | activates | gene | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Brain Insulin Resistance with Glucose Transporter Dysfunctio | 0.398 | neurodegeneration | Metabolic reprogramming in neurodegenera |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-02 | 3 hypotheses Top: 0.398
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Comparative study of the glucolipid profile and GLUTs gene expression in respons [PMID:41232212] | ["Wang Z", "Wang H", "Du P", "Zhang X", | Poultry science | 2025 | 0 |
| Altered Glut4, IRAP, and Brain Insulin Signaling in a Mouse Model of Epilepsy an [PMID:41369048] | ["Xu W", "Neal E", "Barlow N", "Thompson | Journal of neurochemistry | 2025 | 0 |
| Targeting glucose transporters in parkinson's disease: a novel metabolic approac [PMID:40879857] | ["Singh G", "Ansari S", "Aran K"] | Metabolic brain disease | 2025 | 0 |
| Tirzepatide prevents neurodegeneration through multiple molecular pathways. [PMID:38287296] | Fontanella RA, Ghosh P, Pesapane A, Takt | Journal of translational medic | 2024 | 0 |
| A high fat diet potentiates neonatal iron overload-induced memory impairments in [PMID:38358514] | ["do Nascimento F", "de Freitas B", "Dos | European journal of nutrition | 2024 | 0 |
| [WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268] | Wieschollek S, Forster S, Megerle K | Handchirurgie, Mikrochirurgie, | 2022 | 0 |
| Complete Genome Sequence of Geobacter sp. Strain FeAm09, a Moderately Acidophili [PMID:33446582] | Yadav P, Antony-Babu S, Hayes E, Healy O | Microbiology resource announce | 2021 | 0 |
| Engineering complex communities by directed evolution. [PMID:33986540] | Chang CY, Vila JCC, Bender M, Li R, Mank | Nature ecology & evolution | 2021 | 0 |
| Successful Nonoperative Treatment of Osteochondritis Dissecans of the Humeral Ca [PMID:34825100] | Tajika T, Kuboi T, Endo F, Hatori Y, Sai | Progress in rehabilitation med | 2021 | 0 |